This interactive workshop explores the potential of prompt engineering for personalized and active learning with generative AI in STEM related subjects and beyond. Participants will be introduced to YoChatGPT! (www.yochatgpt.io), a novel platform designed to facilitate collaborative learning activities with generative AI. We will also discuss how one may use YoChatGPT! to facilitate self-regulated learning via EdUHK’s 6P pedagogical approach for diverse disciplines.  Come join us and delve into how prompt engineering can enhance student engagement, critical-thinking and problem-solving skills and self-directed learning; and how to leverage YoChatGPT!’s multi-large language model (LLM) chatrooms to design engaging learning experiences, implement active learning strategies and conduct collaborative group work with AI.